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DTSEA: Drug Target Set Enrichment Analysis

It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) &lt;<a href="https://doi.org/10.1016%2Fj.envres.2022.112890" target="_top">doi:10.1016/j.envres.2022.112890</a>&gt; and Feng et al. (2022) &lt;<a href="https://doi.org/10.7150%2Fijms.67815" target="_top">doi:10.7150/ijms.67815</a>&gt; for disease expression profiles; see Wishart et al. (2018) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkx1037" target="_top">doi:10.1093/nar/gkx1037</a>&gt; and Gaulton et al. (2017) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkw1074" target="_top">doi:10.1093/nar/gkw1074</a>&gt; for drug target information; see Kanehisa et al. (2021) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkaa970" target="_top">doi:10.1093/nar/gkaa970</a>&gt; for the details of KEGG database.)



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DTSEA: Drug Target Set Enrichment Analysis

https://cran.rstudio.com/web/packages/DTSEA/index.html

It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) &lt;<a href="https://doi.org/10.1016%2Fj.envres.2022.112890" target="_top">doi:10.1016/j.envres.2022.112890</a>&gt; and Feng et al. (2022) &lt;<a href="https://doi.org/10.7150%2Fijms.67815" target="_top">doi:10.7150/ijms.67815</a>&gt; for disease expression profiles; see Wishart et al. (2018) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkx1037" target="_top">doi:10.1093/nar/gkx1037</a>&gt; and Gaulton et al. (2017) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkw1074" target="_top">doi:10.1093/nar/gkw1074</a>&gt; for drug target information; see Kanehisa et al. (2021) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkaa970" target="_top">doi:10.1093/nar/gkaa970</a>&gt; for the details of KEGG database.)



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https://cran.rstudio.com/web/packages/DTSEA/index.html

DTSEA: Drug Target Set Enrichment Analysis

It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) &lt;<a href="https://doi.org/10.1016%2Fj.envres.2022.112890" target="_top">doi:10.1016/j.envres.2022.112890</a>&gt; and Feng et al. (2022) &lt;<a href="https://doi.org/10.7150%2Fijms.67815" target="_top">doi:10.7150/ijms.67815</a>&gt; for disease expression profiles; see Wishart et al. (2018) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkx1037" target="_top">doi:10.1093/nar/gkx1037</a>&gt; and Gaulton et al. (2017) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkw1074" target="_top">doi:10.1093/nar/gkw1074</a>&gt; for drug target information; see Kanehisa et al. (2021) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkaa970" target="_top">doi:10.1093/nar/gkaa970</a>&gt; for the details of KEGG database.)

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      Drug Target Set Enrichment Analysis [R package DTSEA version 0.0.3]
    • citation_author1
      Junwei Han
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      It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) &lt;<a href="https://doi.org/10.1016%2Fj.envres.2022.112890" target="_top">doi:10.1016/j.envres.2022.112890</a>&gt; and Feng et al. (2022) &lt;<a href="https://doi.org/10.7150%2Fijms.67815" target="_top">doi:10.7150/ijms.67815</a>&gt; for disease expression profiles; see Wishart et al. (2018) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkx1037" target="_top">doi:10.1093/nar/gkx1037</a>&gt; and Gaulton et al. (2017) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkw1074" target="_top">doi:10.1093/nar/gkw1074</a>&gt; for drug target information; see Kanehisa et al. (2021) &lt;<a href="https://doi.org/10.1093%2Fnar%2Fgkaa970" target="_top">doi:10.1093/nar/gkaa970</a>&gt; for the details of KEGG database.)
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