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Synchronization and Random Triggering of Lymphatic Vessel Contractions | PLOS Computational Biology

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Author Summary For decades, cardiovascular physiology has been an area of intense research, and we have a fundamental understanding of the mechanisms the heart uses to drive blood flow through the distributed network of vessels in the body. The lymphatic system is now receiving similar attention as more is learned about its functional role in disease processes. The importance of the lymphatic system in collecting excess fluid from tissues and returning it to the blood is well known, but how the lymph flow is regulated without a central pump is poorly understood. Each segment of collecting lymphatic vessel can independently contract yielding a network of distributed pump/conduits. This paper shows how the lymphatic muscle cells that squeeze fluid along the lymphatic vessels can be effectively regulated using only chemical and mechanical signals that they receive from their immediate microenvironment. Using stability theory and the tools of nonlinear dynamics we identify two complementary oscillators that respond to stretch of the vessel wall and shear of fluid flowing over the vessel wall. Numerical simulations of the combined oscillators show that they have characteristics well suited to the regulation of distributed systems in general and may have application in other biological and physical contexts.

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The lymphatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike the cardiovascular system, lacks a centralized pump-the heart–to drive flow. Instead, each collecting lymphatic vessel can individually contract and dilate producing unidirectional flow enforced by intraluminal check valves. Due to the large number and spatial distribution of such pumps, high-level coordination would be unwieldy. This leads to the question of how each segment of lymphatic vessel responds to local signals that can contribute to the coordination of pumping on a network basis. Beginning with elementary fluid mechanics and known cellular behaviors, we show that two complementary oscillators emerge from i) mechanical stretch with calcium ion transport and ii) fluid shear stress induced nitric oxide production (NO). Using numerical simulation and linear stability analysis we show that the newly identified shear-NO oscillator shares similarities with the well-known Van der Pol oscillator, but has unique characteristics. Depending on the operating conditions, the shear-NO process may i) be inherently stable, ii) oscillate spontaneously in response to random disturbances or iii) synchronize with weak periodic stimuli. When the complementary shear-driven and stretch-driven oscillators interact, either may dominate, producing a rich family of behaviors similar to those observed in vivo.

keywords

Shear stresses,Radii,Eigenvalues,Fluid flow,Muscle contraction,Sound pressure,Lymph,Nitric oxide

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https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005231

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Synchronization and Random Triggering of Lymphatic Vessel Contractions

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Author Summary For decades, cardiovascular physiology has been an area of intense research, and we have a fundamental understanding of the mechanisms the heart uses to drive blood flow through the distributed network of vessels in the body. The lymphatic system is now receiving similar attention as more is learned about its functional role in disease processes. The importance of the lymphatic system in collecting excess fluid from tissues and returning it to the blood is well known, but how the lymph flow is regulated without a central pump is poorly understood. Each segment of collecting lymphatic vessel can independently contract yielding a network of distributed pump/conduits. This paper shows how the lymphatic muscle cells that squeeze fluid along the lymphatic vessels can be effectively regulated using only chemical and mechanical signals that they receive from their immediate microenvironment. Using stability theory and the tools of nonlinear dynamics we identify two complementary oscillators that respond to stretch of the vessel wall and shear of fluid flowing over the vessel wall. Numerical simulations of the combined oscillators show that they have characteristics well suited to the regulation of distributed systems in general and may have application in other biological and physical contexts.

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https://journals.plos.org/ploscompbiol/article/figure/image?id=10.1371/journal.pcbi.1005231.g010&size=inline

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