How do you calculate NMR in stereochemistry? - Answers

In stereochemistry, Nuclear Magnetic Resonance (NMR) spectroscopy is used to determine the structure and stereochemistry of molecules by analyzing the magnetic environments of nuclei, typically hydrogen (¹H) or carbon (¹³C). The chemical shifts, coupling constants, and integration of NMR signals provide insights into the spatial arrangement of atoms, including stereocenters and conformational preferences. By comparing the NMR spectra with known reference compounds or using computational methods, one can deduce the stereochemical configuration of the molecule. Additionally, 2D NMR techniques, such as COSY or NOESY, can reveal connectivity and spatial relationships between protons, aiding in stereochemical assignments.