Definition of the next generation gene sequence? - Answers

Since the advent of next generation sequencing (NGS) technology three decades ago, enormous progress has been made in the fields of Biology and medicine. NGS is a deep, high-throughput, massively parallel or deep sequenced DNA or RNA sequencing technology that has revolutionized genomic research. It is usually used to study genetic variation associated with diseases or other biological phenomena. Currently, NGS technology has been widely used in clinical practice to improve patient care. Compared to traditional Sanger sequencing (first-generation sequencing technology), NGS captures a broader spectrum of mutations and uncovers the human genome without bias. For example, NGS technology unravels the genetic basis of unexplained developmental delays by sequencing affected children and their parents to reveal harmful de novo mutations. Combining these molecular data with detailed clinical phenotypic information, novel genes that mutate in affected children with similar clinical characteristics have been successfully identified. NGS technology has also been used in the current research of some incurable diseases, changing the way a disease is diagnosed, and providing scientists and physicians with fact-based guidelines for the treatment. Recently, a team of researchers from Singapore demonstrated that the next generation sequencing test can detect HIV drug resistance mutations that cannot be identified by the traditional test. This test may play a critical role in helping clinicians to optimize HIV treatment plans, as well as contributing to public health initiatives to minimize the development of global resistance to antiretroviral drugs. Next generation sequencing technology has opened a broad new area of research with the potential to revolutionize personalized cancer medicine. (Go Creative Biolabs)